Advances in Nuclear Oncology:: Diagnosis and Therapy by Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar

By Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar Schober

The diagnostic and healing achievements in radiopharmaceuticals and nuclear drugs instrumentation ? puppy, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT

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Thus, several efforts have focused on the development of further MR-based techniques including diffusion and perfusion imaging, and spectroscopy studies. 3). With this technique, magnetic field gradients are applied before and after the 180i pulse in spin echo imaging sequences. 3 Deep right basal ganglia primary central nervous system lymphoma characterized by a very low signal on T2 images (a), a sharp enhancement after gadolinium (b), and a clear restriction of apparent diffusion coefficient on diffusionweighted images (c) and maps (d).

This implies that it is necessary to use methods that are sensitive and specific for the detection of hemorrhage. Both CT and MRI are useful for depicting the presence of hemorrhage, but the ability of CT to define its etiology is very poor. 35 Furthermore, the evolution of blood within tumor tissue may be slow, as compared to the evolution of benign hematomas. 35 The presence of non-hemorrhagic tumor tissue inside the lesion represents a clear sign of neoplasm. 38 The presence of calcifications in brain tumors is common and it has a diagnostic relevance.

Nearly all of these tumors are benign. Life expectancy is normal if complete surgical removal is achieved and the subsequent hormone deficiency is corrected by drugs. 7,18 25 The incidence rate is low in children and rises steadily with age, reaching its maximum in the seventh and eighth decades. 19 The tumor is characterized by the tendency to spread diffusely throughout the CNS and to the eye; therefore, surgical excision is not considered useful as in other brain tumors. Nevertheless, diagnostic surgery or stereotactic biopsy are necessary to establish a histological diagnosis, showing in almost all cases a malignant large-cell diffuse B-cell lymphoma that expresses pan-B cell markers such as CD20.

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