An Antigen Depository of the Immune System: Follicular by A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H.

By A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. Kosco-Vilbois (eds.)

Follicular dendritic cells (FOe) are certain between cells of the immune approach. whereas their morphological features re­ sulted of their inclusion as a 'dendritic mobile type', tt1ey vary really considerably from the opposite participants of the dendritic phone family members. not like T-cell-associated dendritic cells or the Langerhans cells present in the surface, FOe live in hugely geared up B telephone follicles inside of secondary lymphoid tissues. This web site of resi­ dence supplied a nomenclature committee in 1982 with the second one descriptive issue for the derivation in their identify. The cardinal function of FOe is to capture and continue antigen at the floor in their dendritic tactics for prolonged quantities of time and it's this option that gives the conceptual compo­ nent for the name of this e-book. in keeping with an antigenic problem, fundamental B mobilephone follicles endure dynamic occasions, giving upward thrust to germinal facilities that are linked to activation, enlargement, and differentiation approaches of B cells. The interactions of B cells with Foe and T cells within the germinal facilities are crucial for producing the entire repertoire of antibody isotypes bought in the course of an antibody reaction. furthermore, stimuli both initiated or major­ tained in the course of the germinal heart reponse results in construction of excessive affinity antibodies in the course of the methods of somatic muta­ tion and clonal choice. during this context, FOe act as a pivotal resource of antigen. They collect overseas proteins (e. g.

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1989), enabling such B cells to proliferate better than unlinked B cells. Alternatively, when these receptor cross-lin kings are numerous and extended over the whole cell surface, the B cells could be in a "frozen state" in which activation and proliferation are slowed down. The first situation could arise in the dark zone, where FOC send few cytoplasmic extensions between B cells. The second could occur in the light zone, where, by emperipolesis, the lymphoid cells (centrocytes) are surrounded by FOC extensions and are clearly less activated than centroblasts.

Lymph follicles are always associated with T-dependent zones (HEINEN et al. 1990). so the antigen retained by FOC can serve not only to activate B cells but, when borne by B cells having had contact with FOC, to stimulate T cells. Interactions between T-dependent areas and follicles are not unidirectional (stimulation of virgin B cells before they enter the germinal centers). but bidirectional, since emigrating B cells export and present oligopeptides, thereby maintaining T memory cell clones. Third, interaction via MHC class II molecules can effect other signals.

Immunol Rev 5: Ashman R (1990) B lymphocyte activation: the transferrin receptor as a prototype intermediate activation molecule. J lab Clin Med 116: 759-765 Ashman RF (1984) lymphocyte activation. In: Paul WE (ed) Fundamental immunology. Raven, New York, pp 267-302 Bachman MF, Hoffman-Rohrer U, Kiindig TM, Biirki K, Hengartner H, Zinkernagel RM (1993) The influence of antigen organization of B cell responsiveness. Science 262: 1448-1451 Bancherau J, Rousset F (1992) Human B lymphocytes: phenotype, proliferation and differentiation.

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