Atlas of Heart Diseases: Hypertension: Mechanisms and by Alan B. Weder (auth.), Norman K. Hollenberg MD, PhD (eds.)

By Alan B. Weder (auth.), Norman K. Hollenberg MD, PhD (eds.)

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FIGURE 1-44. Cross-cultural differences between acculturated and less acculturated societies demonstrate the impact of the modern lifestyle on blood pressure. Four relatively primitive populations with a lifestyle and diet probably similar to that of Paleolithic man were included in the INTERSALT Study [51]. The studied populations were characterized by relative leanness, low sodium and high potassium intakes, and little if any alcohol consumption. H 27 0,48 2 1. 7 62. 0 10 . 67. 0 As shown, such societies are virtually free of hypertension and do not demonstrate the progressive rise in systolic blood pressure that is evident in western societies [64].

9 ..... '" Vl A • Clmhm,lllCln diN 86 84 '" 128 -0 8 • ( onlml dil'l 01 rU11 ,md, "1. Id 80 6 78 '9 '"'" 124 Int('rvf'ntion w B k FIGURE 1-51. A, Mean systolic blood pressure (SBP) and B, diastolic blood pressure (DBP) at baseline and during each intervention week, according to diet, for 379 subjects with complete sets of weekly blood pressure measurements. Dietary sodium restriction may not be the key dietary intervention for controlling hypertension. The Dietary Approaches to Stop Hypertension (DASH) trial, a multicenter, randomized feeding study, tested the effects of dietary patterns on blood pressure [73].

26. : Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 1995, 11:76-82. 27. : A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci USA 1995,92:11495-11499. 28. : A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.

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