Bioorganic Chemistry: A Chemical Approach to Enzyme Action by Hermann Dugas

By Hermann Dugas

This widely-praised textbook is very fitted to complicated undergraduates or graduates in chemistry, biochemistry, medicinal chemistry, and pharmacology. The 3rd version has been considerably revised to mirror new learn within the box, and contours an incredible new bankruptcy on self-assembly, auto-organization, and molecular units. the phenomenal figures stay a spotlight of the booklet, and have been defined in an prior variation as "the most sensible i have noticeable for exhibiting the natural chemistry of biomolecules." (Quart. Rev. Biol.)

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Additional info for Bioorganic Chemistry: A Chemical Approach to Enzyme Action

Sample text

This is essentially the way that fidelity of translation in protein biosynthesis is taking place in natural systems. This scheme (Fig. 1). Indeed, it seems most probable that primitive biosystems used a similar concept to carry out primitive protein synthesis where Watson-Crick base pairing provided the intrinsic mechanism for achieving fidelity of replication and direction of protein synthesis. In time, the carrier oligonucleotides could have evolved into more efficient species such as the present-day tRNA molecules.

3 kJ/mol (-7 kcal/mol), and the chlorine atom is a good leaving group. It is therefore possible to convert the carboxyl of an amino acid to an acyl chloride (thionyl chloride, phosphorous pentachloride) and react this with the amino function of a second amino acid to form a peptide bond. This is an oversimplification of the problem of peptide bond (protein) synthesis and, as will be seen shortly, a rather elaborate methodology has been developed. However, it may be of interest to first examine how the peptide bond is synthesized within the biological system, with particular attention to the problem of carboxyl function activation.

4). Unfortunately this action is not restricted to bacterial membranes and so gramicidin S is used only topically. 4 Nonribosomal Peptide Bond Formation D-Phe -----+ r L-Leu +-- L-Pro L-Orn -----+ L-Val +-- L-Val -----+ +-® L-Orn L-Pro -----+ L-Leu 1 +-- D-Phe / NH 3 Orn = ornithine; H2N-(CH2h-CH", COOe Structure of the antibiotic gramicidin s; decapeptide consists of two complementary pentapeptide strands; molecule has a twofold axis of symmetry polypeptide without the need of ribosomes. This process, which occurs only in simple organisms like bacteria, was deciphered by the biochemist F.

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