Combination Therapy of AIDS by Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I.

By Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I. Vandamme (eds.)

HIV an infection has been a better problem to present drugs than the other viral disorder ofmodem instances. HIV results in a continual an infection and the virus has a major genetic flexibility less than selective strain. in the course of its copy­ tive cycle in sufferers, HIV accumulates mutations at this type of excessive fee that the selective strain inflicted at the immune process, or generated through antiviral medications speedily triggers the looks of get away mutants. presently to be had medications, whilst used singly, aren't able to suppressing virus replication in sufferers to this kind of point that the iteration of mutations, from which a variation immune to immune assault or antiviral medicinal drugs might be chosen, is avoided. this is often the most this is because blend remedy, frequently of 3 medications, has develop into the normal method for the therapy ofAIDS. it truly is seen that virus eradication won't simply be a possibility, in order that medicines must be taken for a protracted time or perhaps lifelong on the way to continue the viral load as little as attainable. even if the at the moment used drug combos could be in a position to regulate virus replication in a selected sufferer for one of these professional­ longed time period is determined by many elements, so much of that are addressed within the varied chapters of this publication. the purpose of antiviral drug mixture treatment for AIDS is finally to revive complete functionality of the immune system.

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10th Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA, 10-14 February 2003. A. 1. Vandamme 25 © 2004 Birkhauser Verlag/Switzerland A perspective of the history of HAART Deborah Konopnicki and Nathan Clumeck Saint-Pierre University Hospital, Department of Infectious Diseases, 322 rue Haute, 1000 Brussels, Belgium Introduction The history of HIV treatment is characterised by a rapid development. In 1987, 6 years after the discovery of AIDS, the US Food and Drug administration approved the first drug against HIY.

Antimicrob Agents Chemother 44: 1328-1332 Gong YF, Robinson BS, Rose RE, Deminie C, Spicer TP, Stock D, Colonno RJ, Lin PF (2000) In vitro resistance profile of the human immunodeficiency virus type 1 protease inhibitor BMS232632. Antimicrob Agents Chemother 44: 2319-2326 Poppe SM, Slade DE, Chong KT, Hinshaw RR, Pagano PJ, Markowitz M, Ho DD, Mo H, Gorman RR 3rd, Dueweke TJ et al. (1997) Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor.

3TC ... IOV (START I) d41 ... 31C ... EMV (MKC-302) d4T .. ddl .. 31C (Atlantic) d4T ... 3TC .. IOV (START I) d4T .. dell .. NVP (Atlantic) AZT ... 3TC .. ABC (CNAB3003) d4T .. ddl .. IOV (Atlantic) AZT 3TC .. EFV (DMP-Ooe) d4T 3rc ... EFV (DMP-043) d4T ... 3TC ... EFV (GS-90J) TDF+3TC+ EFV(GS-903) ~~~~~~~~~~~~~~~~~~~~ o 10 20 30 40 50 60 70 80 _ 90 100 Figure 19. Results from clinical trials of various anti-illY drug combinations: percent of patients with HIV load RNA ~ 50 copies/ml at 48 weeks (ITf: intention to treat).

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