Control of Breathing During Sleep and Anesthesia by Witold A. Karczewski (auth.), W. A. Karczewski, P. Grieb,

By Witold A. Karczewski (auth.), W. A. Karczewski, P. Grieb, Joanna Kulesza, G. Bonsignore (eds.)

Contrary to the preferred trust, "Le sommeil n'est plus milieu s(lr" (J. Cocteau, cf. Cl. Gaultier, Pathologie respiratoire du sommeil, los angeles Presse Medicale, sixteen, 561-563, 1987), and anesthesia is even much less secure. unexpected youngster dying Syndrome, Obstructive Sleep Apnea, Ondine's Curse and numerous breathing problems of normal anesthesia aren't so infrequent; in fact they occur a lot too usually. the belief of organizing one other symposium facing inhaling sleep and anesthesia has been mentioned presently when we stated "good bye" to the Organizers of the superb Paris assembly "The legislation of breathing in the course of Sleep and Anesthesia" (R.S. Fitzgerald, H. Gautier, S. Lahiri eds., Advances in Experimental drugs and Biology, vol. ninety nine, Plenum, big apple 1978). making an allowance for the outstanding quantity of knowledge that experience emerged over the last few years, we have now made up our minds that we will meet and talk about them; we was hoping additionally that the booklet of the medical fabric should help for everyone attracted to the body structure and pathophysiology of respiring, anesthesia and sleep. So we met in Warsaw less than the auspices of the eu Society for scientific breathing body structure and the Polish Academy of Sciences, we mentioned vividly many desirable papers offered by means of our Colleagues from Europe and the USA and Plenum Press has released the court cases. i am hoping that the ultimate end result will fulfill the reader.

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ROLE OF UPPER SLEEP APNEA AIRWAY MUSCLES IN CENTRAL AND OBSTRUCTIVE Apneas of the central and obstructive types are the most obvious abnormalities of breathing that occur during sleep (Cherniack, 1984). , 1987a). Many apneas begin with a central component and are prolonged by an obstructive phase. Although it was once believed that two different forms of apnea were produced by entirely separate mechanisms, it now seems probable that they have a 32 common or1g1n. , 1982). There may, however, be important differences in the or1g1n of single as opposed to recurrent apneic events.

Of Sa02 impairment, as expressed by parameters like mean sleep Sa02, lowest nocturnal Sa02, percentage of sleep time below a particular Sa02 level. THERAPEUTIC APPROACHES Obstructive Sl eep Apnea Syndrome Because of the common cause, treatment of hypoxemia in OSAS is closely related to the prevention of obstructive apneas. However, attempts to reverse hypoxemi a independently of the treatment of apneas have been performed with 02 administration. A higher pre-apneic Sa02, set by 02 administration, could be responsible for a less severe hypoxemic level f ollowing each apnea.

93: 391. , 1986, Hypercapnia in the obstructive sleep apnea syndrome. An evaluation of the "Pickwickian syndrome", Chest, 89: 627. , 1986, Effects of 2 and 4 1/min oxygen breathing on pulmonary artery pressure. Blood gases and sleep stages in patients with chronic obstructive lung disease, Eur. ~ Respir. 146): 443. , 1978, Hemodynamic studies in sleep apnea, in: "Sleep apnea syndromes", C. C. , New York. , 1980, The cardiorespiratory effects of obesity, Clin. , 1: 103. , 1985, Relationship of ventricular ectopy to nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease, Am.

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