By Vladimir Uversky, Sonia Longhi
This publication presents up to date info on experimental and computational characterization of the structural and practical houses of viral proteins, that are greatly interested in regulatory and signaling techniques. With chapters by means of major examine teams, it gains present info at the structural and sensible roles of intrinsic problems in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, wooded area virus, bovine virus, hepatitis, and rotavirus in addition to viral genomics. After studying the original positive factors of every category of viral proteins, destiny instructions for study and ailment administration are provided.
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Extra info for Flexible Viruses: Structural Disorder in Viral Proteins (Wiley Series in Protein and Peptide Science)
Some of the triangular faces are made up of four subunits. CLASSIFICATION AND FUNCTIONS OF VIRAL PROIEINS 7 Therefore, there are typically 12 capsomers in the icosahedral virus. Many viruses have more than 60 subunits. In these viruses with large icosahedral capsids, the triangular faces are made up of four subunits (Fig. 1c). Capsids of several viruses are neither purely helical nor purely icosahedral. These complex capsids may include extra structures, such as protein tails or complex outer walls.
Nature 1989;340:467-468. o R. Solid-state NMR data support a helix-loop-helix structural model for the N-terminal half of HIV -1 Rev in fibrillar form. J Mol Biol2001;313:845-859. Boxer EL, Nanda SK, Baron MD. The rindetpest virus non-structural C protein blocks the induction of type 1 interferon. VIrology 2009;385:134-142. 24 INIRINSIC DISORDER IN VIRAL PROTEINS Bo:ms M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L. V-1 Tax interactome. Retrovirology 2008;5:76. Brazil DP, Hemmings BA.
Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J 2005;272: 5129-5148. Dunker AK, Lawson JD, Brown CJ, Williams RM, Romero P, Oh JS, Oldfield CJ, Campen AM, Ratliff CM, Hipps KW, Ausio J, Nissen MS, Reeves R, Kang C, Kissinger CR, Bailey RW, Griswold MD, Chiu W, Garner EC, Obradovic Z. Intrinsically disordered protein. J Mol Graph Model2001;19:26-59. Dunker AK, Obradovic Z, Romero P, Garner EC, Brown CJ. Intrinsic protein disorder in complete genomes. Genome Inform SerWorkshop Genome Inform 2000;11:161-171.