Growth Factors in Reproduction by Shelton Earp, William Huckle, Victoria Raymond, Leslie

By Shelton Earp, William Huckle, Victoria Raymond, Leslie Petch, Sherry Marts (auth.), David W. Schomberg PhD (eds.)

The severe position of progress components in general in addition to irregular mobile development and serve as has develop into overwhelmingly obvious in recent times. the numerous advances in reproductive biology inside of this quickly increasing box have been highlighted on the Serono Symposia, united states, symposium entitled progress components in Reproduc­ tion. The convention excited about development elements as polyfunctional regulators of progress and improvement within the reproductive process. this system used to be geared up into 5 parts: (1) progress components as polyfunctional regulators of progress and improvement, (2) progress components and gonadal functionality, (3) rules of ordinary and neoplastic mammary development, (4) regulatory peptides in reproductive tract improvement and serve as, and (5) embryo-maternal signaling. This quantity constitutes the contributions ofthe invited symposium audio system and is equipped into sections representing the 5 subject parts of the periods. Drs. Eli Y. Adashi, Robert B. Dickson, David C. Lee, James Hammond, John A. McLachlan, and R. Michael Roberts, who served as chairmen ofthese periods, not just supplied important recommendation and advice in organizing the symposium, yet contributed considerably to its content material. the keenness and esprit de corps of the poster presenters and dialogue members additionally helped make this symposium be successful because the first of its type. ultimately, specific thank you are due Drs. James Posillico and Lisa Kern ofSerono Symposia, united states, for his or her tips and help within the belief and making plans of the symposium and within the booklet of this volume.

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A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family. Nature 1987;325:81-4. 24. Weeks DL, Melton DA. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-~. Cell 1987;51:861-7. 25. Lyons K, GraycarJL, Lee A, et al. Vgr-l, a mammalian gene related to Xenopus Vg-l, is a member of the transforming growth factor ~ gene superfamily. Proc Natl Acad Sci USA 1989;86:4554-8. 26. Wozney JM, Rosen V, Celeste AJ, et al.

McCune BK, Earp HS. EGF-dependent suppression of epidermal growth factor receptor autophosphorylation in liver epithelial cells is transient and is not due to activation of protein kinase C. J BioI Chem (in press). 56. Earp HS, Austin KS, Blaisdell J, et al. Epidermal growth factor (EGF) stimulates EGF receptor synthesis. J BioI Chem 1986;261:4777-80. 57. Earp HS, Hepler JR, Petch LA, et al. Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF receptor protein synthesis and mRNA levels in rat liver epithelial cells.

Furthermore, TGFa is reported to influence cell migration (32); thus, its expression in the decidua (especially as a gradient) may help direct the influx of fetal cells. Finally, it is also possible that TGFa produced in the decidua is localized to the fetus through presently unknown transport mechanisms. BIOLOGICAL PROPERTIES OF THE TRANSMEMBRANE TGFa PRECURSOR Analysis of the human (33) and rat (14) TGFa cDNAs suggested that the mature growth factor is proteolytically cleaved from a glycosylated precursor protein of 159 or 160 amino acids.

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