By B. S. Weir (auth.), Bruce S. Weir (eds.)
The ongoing debate at the use of DNA profiles to spot perpetrators in legal investigations or fathers in paternity disputes has too frequently been carried out without regard to sound statistical, genetic or criminal reasoning. The members to Human id: The Use ofDNA Markers all have enormous event in forensic technological know-how, statistical genetics or jurimetrics, and plenty of of them have needed to clarify the medical matters concerned about utilizing DNA profiles to judges and juries. even supposing the authors carry differing perspectives on many of the concerns, they've got all produced money owed which pay due consciousness to the, occasionally troubling, problems with independence of elements of the profiles and of inhabitants substructures. The publication offers the huge evolution of principles that has happened because the 1992 document of the nationwide study Council of the U.S.
Audience: fundamental to forensic scientists, laying out the ideas to all people with an curiosity within the use of genetic info. The chapters and exhaustive bibliography are very important details for all attorneys who needs to prosecute or protect DNA instances, and to judges attempting such situations.
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The continuing debate at the use of DNA profiles to spot perpetrators in felony investigations or fathers in paternity disputes has too usually been performed with out regard to sound statistical, genetic or criminal reasoning. The members to Human identity: The Use ofDNA Markers all have significant adventure in forensic technology, statistical genetics or jurimetrics, and plenty of of them have needed to clarify the clinical concerns desirous about utilizing DNA profiles to judges and juries.
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Extra info for Human Identification: The Use of DNA Markers
J. Narn, 1984. A score test for the possible presence of recessive alleles in generalized ABO-like genetic systems. Biometrics 40: 887-894. J. & J. Nam, 1988. The equivalence of two tests and models for HLA data with no observed double blanks. Biometrics 44: 869-873. Geisser, S. & W. Johnson, 1992. Testing Hardy-Weinberg equilibrium on allelic data from VNTR loci. Am. J. Hum. Genet. 51: 1084-1088. Geisser, S. & W. Johnson, 1993. Testing independence of fragment lengths within VNTR loci. Am. J.
The authors take explicit account of these alleles, and are able to show independence of the frequencies of detectable alleles. They raise the troubling issue of how to account for occasional significant results when multiple tests are performed. By invoking Bonferroni corrections, they regard all tests, even those petformed on different loci, as addressing the same hypothesis~the absence of dependence at any VNTR locus. S. ), Human Identification: The Use of DNA Markers, 37-49, 1995. © 1995 Kluwer Academic Publishers.
Genet. 55:391-401. , 1990. DNA fingerprinting for forensic identification: potential effects on data interpretation of subpopulation of heterogeneity and band number variability. Am. J. Hum. Genet. 46: 358-368. Devlin, B. & N. Risch, 1992. A note on Hardy-Weinberg equilibrium of VNTR data by using the Federal Bureau of Investigation's fixed-bin method. Am. J. Hum. Genet. 51:549-553. Devlin, B. & N. Risch, 1993. Physical properties of VNTR data, and their impact on a test of allelic independence.