Interferons: Mechanisms of Action and Role in Cancer Therapy by Derek Crowther (auth.), Professor Derek Crowther (eds.)

By Derek Crowther (auth.), Professor Derek Crowther (eds.)

A good deal of recent details has been acquired in past times 4 years, and this monograph offers a transparent and good reviewed replace on biochemical mechanisms and the result of vital new medical stories utilizing the interferons. studies comprise what's almost immediately identified concerning the biosynthesis, physiological function and mechanisms of motion of the interferons (alpha, beta, gamma). New biochemical details on interferon-receptor interactions and signalling pathways is supplied. The pharmacokinetic concerns in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and different stable tumors are reviewed with precise emphasis on experiences of adjuvant chemotherapy in malignancies of the immune system.

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Intralesional and low dose in tram uscular therapy. Arch Dermatol 1987 (123):757-763 65 Kaplan EH, Rosen ST, Norris DB et al: Phase II study of recombinant human interferon gamma for treatment of cutaneous T cell lymphoma. JNCI1990 (82):208-212 66 Gresser I, Brouty-Boye D, Thomas M-T: Inhibition of the multiplication of mouse leukaemia L1210 cells in vitro by an IFN preparation. Proc Nat Acad Sci 1970 (66):1052 67 Gresser I, Maury C, Brouty-Boye D: Mechanism of the anti-tumour effect of IFN in mice.

Kyle et a!. [43] reported in a non-randomised study that 80% of previously untreated patients responded to VBMCP + alpha-IFN and that 26% of the patients achieved a complete remission. Using a combination of VMCP and alpha-IFN compared to VMCP alone, Ludwig et a!. [44] demonstrated superiority of the IFN-containing regimen for response induction, 57% vs. 41%. Interferon as Maintenance Therapy Another approach for alpha-IFN in multiple myeloma has been explored by the Italian Multiple Myeloma Study Group.

A randomized clinical trial. Cancer Treat Rep 1984 (68):1331-1338 Mellstedt H, for the Myeloma Group of Central Sweden (MGCS): MP/alpha-IFN in the induction treatment of multiple myeloma and as maintenance therapy. - A randomized trial from MGCS. Abstract. IIIrd International Workshop on Multiple Myeloma, Torino, April 9-12,1991 33 37 Osterborg A and Mellstedt H: Induction therapy with interferon in multiple myeloma and possible mechanisms of action. In: Gutterman J, Talpaz M (eds) Biological Response Modifiers in Hematological Malignancies.

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