Peroxisome Proliferator Activated Receptors: From Basic by Sander Kersten, Béatrice Desvergne, Walter Wahli (auth.),

By Sander Kersten, Béatrice Desvergne, Walter Wahli (auth.), J.-C. Fruchart, A. M. Gotto Jr., R. Paoletti, B. Staels, A. L. Catapano (eds.)

Peroxisome Proliferator Activated Receptors (PPARs) allure nice consciousness in gentle of the large spectrum of genes of organic and scientific relevance pointed out as lower than their keep watch over. accordingly, our wisdom of the position of those receptors in body structure and pathology maintains to develop at a quick speed and PPARs became a fascinating goal for the remedy of many pathological stipulations, together with diabetes and atherosclerosis. This quantity offers an authoritative view of the present scientific and clinical advancements inside of this evolving zone of study.

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Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications

Peroxisome Proliferator Activated Receptors (PPARs) allure nice recognition in gentle of the vast spectrum of genes of organic and scientific relevance pointed out as lower than their keep an eye on. accordingly, our wisdom of the function of those receptors in body structure and pathology keeps to develop at a quick speed and PPARs became an attractive objective for the therapy of many pathological stipulations, together with diabetes and atherosclerosis.

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Prevention of atherosclerosis in apolipoprotein Edeficient mice by bone marrow transplantation, Science 1995;267:1034-37. PPARsANDATHEROGENESIS:MEDIATORSORMoDULATORSOFTHEINFLAMMATORY RESPONSE IN THE VESSEL WALL? Nikolaus Marx Introduction Within the last couple of years, peroxisome proliferator-activated receptors (pPARs) have received growing interest in vascular biology and atherosclerosis. Recent data in vascular cells suggested that PP ARs, initially identified as regulators of lipid metablosim and adipogenesis, might have anti-inflammatory effects in atherogenesis.

Nat Med 2001;7(1):48-52. Chinetti G, Lestavel S, Bocher V, et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the 33 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. ABCAI pathway. Nat Med 2001;7(1):53-58. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998;93(2):24152. Febbraio M, Podrez EA, Smith JD, et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.

Smooth Muscle Cells Activated SMC increase the inflammatory response via an enhanced cytokine production. PPARa activation inhibits IL-I ~-induced expression oflL-6 and prostaglandin production in human aortic SMC [18] (Figure 2). PPARy has also been shown to affect SMC function since PPARy ligands inhibit the proliferation and migration of vascular SMC [10,46]. In addition, PPARy activation reduces phorbolester-induced expression ofMMP-9 [17] thus contributing to the inhibition ofextracellular matrix (ECM) degradation leading to cell migration and plaque instability.

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