Principal component analysis - multidisciplinary by Parinya Sanguansat

By Parinya Sanguansat

This booklet is aimed toward elevating understanding of researchers, scientists and engineers at the merits of central part research (PCA) in facts research. during this booklet, the reader will locate the purposes of PCA in fields equivalent to taxonomy, biology, pharmacy,finance, agriculture, ecology, healthiness and structure.

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Genetics data record that the status of some nucleotides found at a certain position in the genome are different from one person to another. These baseand position-specific person-to-person variations are known as SNP or Single Nucleotide Polymorphism. When the frequency of the variation in a population is greater than 1%, this variation is considered as a true polymorphism possibly associated with traits (phenotypes) and genetic diseases (mutations). Moreover this information is useful as a genetic biomarker for susceptibilities to multigenic diseases or ancestrality and migration studies.

1997) Exploring the Metabolic and Genetic Control of the Gene Expression on a Genomic Scale. Science, 278, 681 – 686. & Novembre, J. (2010) Principal component analysis under population genetic models of range expansion and admixture. Molecular Biological Evolution, 27, 6, 1257-1268. Freiwald, A. & Sauer, S (2009) Phylogenetic classification and identification of bacteria bymass spectrometry”, Nature protocols, 4, 5, 732-742. International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome, Nature, 409,860-921.

C. d. e. f. e. the API and additives (excipients), optimisation of the composition of the formulation with respect to API and excipients, scale-up to larger throughput (industrial scale), optimisation and validation of the processing steps for the manufacturing; monitoring processing steps during manufacture, quality assurance of the finished product, the tablet. Tablets have been produced for more than 100 years in large quantities, and their quality has always been an issue; therefore the technical factors that influence tablet properties have been studied extensively.

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