Testosterone: Action - Deficiency - Substitution by Focko F. G. Rommerts (auth.), Prof. Dr. med. Eberhard

By Focko F. G. Rommerts (auth.), Prof. Dr. med. Eberhard Nieschlag, Priv.-Doz. Dr. med. Hermann M. Behre (eds.)

New advancements in testosterone motion and remedy are summarized the following through the world over well known specialists. They evaluation either easy and scientific wisdom in 20 chapters. This second variation has been completely revised and prolonged. The publication provides the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of motion in objective organs. results on bones, muscle tissues, lipids, hair, the prostate, and the mind are thought of in separate chapters. Syndromes as a result of androgen resistance are defined as a way to spotlight the significance of competently functioning enzymes and receptors within the aim organs. The pharmacology, pharmacokinetics and medical makes use of and abuses of testosterone arrangements are mentioned intimately, and unintended effects of testosterone remedy are reviewed. this can be the cutting-edge ebook approximately testosterone motion and remedy for endocrinologists, andrologists, urologists and pharmacologists.

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1989; Henttu and Vihko 1993; Lindzey et al. 1993; Sanborn et al. 1991). 3 Androgen receptor protein The AR is a member of the group of four closely-related steroid receptors that also includes the progesterone receptor (PR), glucocorticoid receptor 37 38 c. A. Quigley (GR) and mineralocorticoid receptor (MR) - sometimes referred to as the "GR-like" receptors. These four receptors, related by their sequence homology and also by their ability to activate target gene transcription via the same HRE, comprise a sub-group of the larger and more diverse family of nuclear transcription factors that includes the estrogen receptor (ER), thyroid hormone receptors (TRa and TRf3), vitamin D receptor (VDR), retinoic acid receptor (RAR), retinoid X receptor (RXR), and a number of related receptors for which ligands have not yet been identified in many cases.

J Androl 9:343-351 1 Testosterone: An overview of biosynthesis, transport, metabolism and nongenomic actions Themmen APN, Martens JWM, Brunner HG (1997) Gonadotropin receptor mutations (review). J EndocrinoI153:179-183 Trager L (1977) Steroidhormone: Biosynthese, Stoffwechsel, Wirkung. Springer Verlag, Berlin, pp 164-197. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R (1992) Human P-glycoprotein transports cortisol, aldosterone and dexamethasone but not progesterone.

These conjugated steroids carry a charged group such as a sulphate or a glucuronide group on the 3- or 17-position. Dehydroepiandrosterone-sulphate is a well-known example of a conjugated steroid which is produced by the adrenal cortex and which is present in the circulation at micromolar levels without a clear physiological function, although certain abnormalities may have connections with alterations in the plasma levels of DHEA-sulphate (Ebeling and Koivisto 1994). In adult men, glucuronides of the 5fJ-androstane compounds are most abundant.

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