By M. A. Epstein, B. G. Achong (auth.), M. A. Epstein M.A., M.D., Ph.D., D.Sc., F.R.C. Path., F.R.S., B. G. Achong M.B., B.Ch., B.A.O., M.D. (eds.)
The Epstein-Barr virus was once came upon 15 years in the past. because that point an important physique of knowledge has been accumu lated in this agent which has come to imagine nice signifi cance in lots of diverse fields of organic technological know-how. therefore, the virus has very designated relevance in human medication and oncology, in tumor virology, in immunology, and in mole cular virology, because it is the reason for infectious mononu cleosis and likewise the 1st human melanoma virus, etiologically concerning endemic Burkitt's lymphoma and possibly to nasopharyngeal carcinoma. furthermore, non-stop human lymphoid phone traces initiated and maintained through the remodel ing functionality of the virus genome supply a laboratory instrument with broad and ever-growing functions. Innumerable papers at the Epstein-Barr virus have ap peared over fresh years and reviews of labor with this agent now represent a veritable flood. the current e-book offers the 1st and in simple terms entire, authoritative over-view of all facets of the virus by way of authors who've been the unique and significant members of their specific disciplines. an entire and up to date survey of this particular and critical agent is hence supplied which might be of significant curiosity to specialists, academics, and scholars engaged in melanoma learn, virology, immunology, molecular biology, epide miology, and mobile tradition. the place subject matters were handled from a couple of of those viewpoints, a few inevitable overlap and duplication has resulted; even supposing this has been saved to a minimal, it's been retained in a few areas due to confident usefulness.
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Extra resources for The Epstein-Barr Virus
Epstein, M. , Giovanella, B. : Isolation of infectious EB virus from the epithelial tumour cells of nasopharyngeal carcinoma. Int. 1. , Grace, J. : Structure of virus particles extracted from a Burkitt lymphoma cell line. J. Viro!. : EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228,10561058 (1970) 3 EB Virus-Induced Antigens I. Ernberg and G. Klein Department of Tumor Biology, Karolinska Institutet, S-10401 Stockholm 60 (Sweden) A. Introduction. .
Int. J. , Kourilsky, F. : Differentiation between early and late membrane antigen on human lymphoblastoid cell lines infected with Epstein-Barr virus. II. Immunoelectron microscopy. J. Nat!. Cancer Inst. 53, 67-74 (1974) Solomon, 1. , Witter, R. , Burmester, B. : Studies on the etiology of Marek's disease. I. Propagation of the agent in cell culture. Proc. Soc. Exp. Bio!. Med. 127, 173-177 (1968) Stewart, S. , Whang, J. , Ngu, V. : Burkitt tumor: tissue culture, cytogenetic and virus studies. J.
Monroe, J. H. : Transformation and chromosome changes induced by EpsteinBarr virus in normal human leukocyte cultures. Proc. Natl. Acad. Sci. , Goldstein, L. : Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis. , Nkrumah, F. : Comparative studies of Epstein-Barr virus strains from Ghana and the United States. Int. J. : Host cell macromolecular synthesis in cells containing EBV-induced early antigens, studied by combined immunofluorescence and radioautography.